Stem cells in tissues, organoids, and cancers

    July 2019 in “ Cellular and Molecular Life Sciences ”
    Xusheng Wang
    TLDR Stem cells are crucial for tissue growth, cancer treatment, and disease modeling, but challenges remain in clinical use.
    The document discussed the critical role of stem cells in tissue formation, tumor development, and their ability to generate 3D organoids. It highlighted the importance of understanding stem cell heterogeneity, plasticity, and epigenetic modifications, which are influenced by niche signals, in improving tissue homeostasis and developing cancer treatments. The study of stem cell-derived organoids was noted for its potential in modeling human diseases and advancing regenerative medicine. Despite these advancements, the document acknowledged that significant challenges remained in applying stem cell research effectively in clinical settings.
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