Preservation of Stem Cells in Androgenetic Alopecia

October 2017 in “ Journal of The European Academy of Dermatology and Venereology ”

Hend Gamil, Magda Assaf, Mohamed A. Elsayed, K. Gharib, Mohamed Y. Soliman, N.A. Mostafa

androgenetic alopecia follicular stem cells bulge region CD34+ cells progenitor cells follicular miniaturization AGA stem cells

TLDR Stem cells preservation in AGA could be a potential therapy, but more cases needed.

This study aimed to evaluate the expression of stem and progenitor cell markers in scalp biopsies from patients with androgenetic alopecia (AGA). The study included 20 patients with AGA, and the results showed that follicular stem cells in the bulge region are not the target of AGA. The loss of CD34+ cells supports the view that a defect in the conversion of bulge stem cells to active progenitor cells may play a role in follicular miniaturization and disease progression. The study suggests that the preservation of stem cells in AGA may be a potential therapeutic target. However, the limitation of the study was the number of cases, which should be increased.

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