Preservation of Stem Cells in Androgenetic Alopecia

October 2017 in “ Journal of The European Academy of Dermatology and Venereology ”

Hend Gamil, Magda Assaf, Mohamed A. Elsayed, K. Gharib, Mohamed Y. Soliman, N.A. Mostafa

androgenetic alopecia follicular stem cells bulge region CD34+ cells progenitor cells follicular miniaturization AGA stem cells

TLDR Stem cells preservation in AGA could be a potential therapy, but more cases needed.

This study aimed to evaluate the expression of stem and progenitor cell markers in scalp biopsies from patients with androgenetic alopecia (AGA). The study included 20 patients with AGA, and the results showed that follicular stem cells in the bulge region are not the target of AGA. The loss of CD34+ cells supports the view that a defect in the conversion of bulge stem cells to active progenitor cells may play a role in follicular miniaturization and disease progression. The study suggests that the preservation of stem cells in AGA may be a potential therapeutic target. However, the limitation of the study was the number of cases, which should be increased.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

6 / 6 results

research Stem Cells and the Skin

22 citations, November 2012 in “Journal of cosmetic dermatology”

Stem cells can rejuvenate skin, restore hair, and aid in wound healing.

research Stem Cells and Alopecia: A Review of Pathogenesis

33 citations, April 2012 in “British Journal of Dermatology”

Damaged hair follicle stem cells can cause permanent hair loss, but understanding their role could lead to new treatments.

research Guidelines for the Management of Androgenetic Alopecia (2010)

38 citations, December 2011 in “Journal of Dermatology”

Use minoxidil for hair loss treatment, and finasteride for men.

Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

research Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

235 citations, January 2011 in “Journal of Clinical Investigation”

Men with baldness due to androgenetic alopecia still have hair stem cells, but lack specific cells needed for hair growth.

research Stem Cell Markers (Cytokeratin 15, CD34, and Nestin) in Primary Scarring and Nonscarring Alopecia

54 citations, January 2009 in “British Journal of Dermatology”

Scarring alopecia affects different hair follicle stem cells than nonscarring alopecia, and the infundibular region could be a new treatment target.

research Pathobiology of Androgenetic Alopecia

5 citations, November 2003 in “Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc Czech Republic”

The exact causes of baldness are not fully understood, limiting treatment options.

Related Community Posts Join

6 / 1000+ results

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community HairClone developing cell replacement treatments for Hair Loss

6 upvotes 6 years ago

HairClone is developing cell replacement treatments to rejuvenate and generate hair follicles, and has launched a crowdfunding campaign. A user expressed skepticism about the need for crowdfunding.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community New Treatments, and a Huge Group Buy with Lots of Research

in Research/Science 109 upvotes 1 year ago

A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 667 upvotes 2 months ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community COMPLETE OVERVIEW of the Treatment of androgenetic alopecia in men

26 upvotes 10 years ago

Male androgenetic alopecia is commonly treated with topical minoxidil and oral finasteride, both requiring continuous use. Other options include hair restoration surgery, dutasteride, light therapy, and camouflaging agents.

Related Research

3 / 3 results

research Comparative Study of Efficacy of Topical Minoxidil 5% and Combination of Topical Minoxidil 5%, Topical Azelaic Acid 1.5% and Topical Tretinoin 0.01% Based on Dermoscopic Analysis in Androgenetic Alopecia

1 citations, September 2015 in “MVP journal of medical science”

Topical Minoxidil 5% is as effective as the combination treatment for hair loss.

research Primary Cicatricial Alopecia: Diagnosis and Treatment

48 citations, May 2013 in “Canadian Medical Association Journal”

Primary cicatricial alopecia, a rare disorder causing permanent hair loss, is hard to diagnose and treat, with treatments like anti-inflammatory drugs and steroids offering varied results and no guaranteed cure. Psychological support for patients is important, and future research should aim to identify causes of the condition.

research Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

235 citations, January 2011 in “Journal of Clinical Investigation”

Men with baldness due to androgenetic alopecia still have hair stem cells, but lack specific cells needed for hair growth.