Association Between SQSTM1 Dysregulation and Risk in Alopecia Areata: A Mendelian Randomization Study

November 2025 in “ Frontiers in Immunology ”

Lifang Hu, Sheng Wan, Xiuzu Song

SQSTM1 alopecia areata Mendelian randomization pathophysiology AA

Studysummary In this study, researchers found significant links between specific metabolic reprogramming-related genes and alopecia areata risk, highlighting increased SQSTM1 expression in affected hair follicles compared to healthy ones.

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This study highlights a significant association between the dysregulation of the SQSTM1 gene and the risk of developing alopecia areata (AA). By employing a Mendelian randomization approach, the research advances our understanding of the pathophysiology of AA, suggesting that SQSTM1 may play a crucial role in the development of this condition. The findings provide a potential target for future therapeutic interventions aimed at managing or preventing AA.

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research The Regulatory Mechanisms of Mitophagy and Oxidative Stress in Androgenetic Alopecia

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research Integrative Analysis of Rare Copy Number Variants and Gene Expression Data in Alopecia Areata Implicates an Etiological Role for Autophagy

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Association Between SQSTM1 Dysregulation and Risk in Alopecia Areata: A Mendelian Randomization Study

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