Association Between SQSTM1 Dysregulation and Risk in Alopecia Areata: A Mendelian Randomization Study

November 2025 in “ Frontiers in Immunology ”

Lifang Hu, Sheng Wan, Xiuzu Song

SQSTM1 alopecia areata Mendelian randomization pathophysiology AA

TLDR SQSTM1 gene issues may increase the risk of alopecia areata.

This study highlights a significant association between the dysregulation of the SQSTM1 gene and the risk of developing alopecia areata (AA). By employing a Mendelian randomization approach, the research advances our understanding of the pathophysiology of AA, suggesting that SQSTM1 may play a crucial role in the development of this condition. The findings provide a potential target for future therapeutic interventions aimed at managing or preventing AA.

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