Association Between SQSTM1 Dysregulation and Risk in Alopecia Areata: A Mendelian Randomization Study

    November 2025 in “ Frontiers in Immunology ”
    Lifang Hu, Sheng Wan, Xiuzu Song
    Studysummary In this study, researchers found significant links between specific metabolic reprogramming-related genes and alopecia areata risk, highlighting increased SQSTM1 expression in affected hair follicles compared to healthy ones.
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    Research cited in this study 6

    1. The Regulatory Mechanisms of Mitophagy and Oxidative Stress in Androgenetic Alopecia Cellular Signalling · 2025
    2. Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management Clinical Reviews in Allergy & Immunology · 2021
    3. Integrative Analysis of Rare Copy Number Variants and Gene Expression Data in Alopecia Areata Implicates an Etiological Role for Autophagy Experimental Dermatology · 2019
    4. Stimulation of Hair Growth by Small Molecules That Activate Autophagy Cell reports · 2019
    5. Alopecia Areata: An Autoimmune Disease Causing Hair Loss The New England Journal of Medicine · 2012
    6. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010