Skin and Hair Follicle Aging: From Clinical Characterization to Functional Study

The study explored the multifactorial nature of aging in skin and hair follicles, identifying key mechanisms such as mitochondrial dysfunction and telomere shortening. In vivo research revealed early clinical markers of androgenic alopecia, like peripilar signs and hair diameter diversity, linked to biological factors such as inflammatory infiltrates and follicle miniaturization. In pre-menopausal women, a connection between iron status and hair loss was established. Additionally, the study examined the effects of topical DHEA on menopausal skin, identifying a biological signature at both dermal and epidermal levels, and characterized the impact of a glycosaminoglycan C-Xyloside precursor on skin compartments.