Skin and Hair Follicle Aging: From Clinical Characterization to Functional Study

The study explored the multifactorial nature of aging in skin and hair, identifying key mechanisms such as mitochondrial dysfunction and telomere shortening. It revealed early clinical markers of androgenic alopecia, like peripilar signs and hair diameter diversity, and linked them to biological factors such as inflammatory infiltrates and follicle miniaturization. In pre-menopausal women, a connection between iron status and hair loss was established. Additionally, the study identified a biological signature in menopausal women's skin in response to DHEA application and characterized the effects of a glycosaminoglycan C-Xyloside precursor on skin compartments.