Skin Diseases in Pregnancy

The 2000 document outlines the range of skin changes and diseases that can occur during pregnancy, such as hyperpigmentation, stretch marks, cholestasis of pregnancy, and pruritic urticarial papules and plaques of pregnancy (PUPPP). It highlights the need for cautious therapeutic interventions to avoid fetal risks, advising against systemic therapy in the first trimester and careful use of topical treatments. The document reports that skin conditions like acne and psoriasis may improve or worsen during pregnancy, with a study of almost 3200 women showing a 1.6% risk of cutaneous problems. It also addresses the management of skin tumors, noting hormonal influences on melanocytic nevi and malignant melanomas. Additionally, it describes rare conditions such as prurigo of pregnancy, autoimmune progesterone dermatitis, and pruritic folliculitis of pregnancy, emphasizing the lack of specific laboratory findings for diagnosis and the need for a comprehensive study to better understand these conditions. Therapy is generally symptomatic, and the differential diagnosis is broad for these dermatoses.