Silymarin in Combination with Hair Follicle Transplantation as a Potential Treatment for Refractory Vitiligo: A Double-Blind Randomized Controlled Trial

This study explored the effectiveness of combining silymarin with hair follicle transplantation for treating refractory vitiligo in a double-blind randomized controlled trial with 20 participants. Results showed that the combination therapy led to significantly greater peri-follicular re-pigmentation over 3 months compared to transplantation alone, with statistically significant differences at each monthly follow-up. The study concluded that this combination could be a more effective treatment option for refractory vitiligo, with minimal complications. However, due to the small sample size, further research with larger populations is recommended to validate these findings.