Isolation and Characterization of a Sheep Cysteine-Rich Cuticle Keratin Pseudogene

    January 1992 in “ DNA sequence ”
    Brendan J. Jenkins, Barry C. Powell
    TLDR Researchers found a non-functional sheep keratin gene due to mutations.
    Researchers characterized a sheep cuticle keratin gene and identified a related pseudogene through sequencing. This pseudogene, which arose from gene duplication, was non-functional due to key mutations in its promoter and processing signals, as well as the presence of two in-frame termination codons. A recombination point between sequences encoding glycine-rich repeats may have contributed to these termination codons. The study highlighted the evolutionary conservation of cysteine-rich keratin proteins and provided insights into the genetic mechanisms leading to pseudogene formation.
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