Sex Differences in the Effect of Finasteride on Acute Ethanol Withdrawal Severity in Mice: Thesis
January 2006
New to Finasteride? There is a guide in the encyclopedia. Read the guide → Studysummary This study found that finasteride increased acute ethanol withdrawal severity in female mice, while decreasing it in male mice, suggesting sex differences in sensitivity to finasteride's effects.
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The study investigated the effects of finasteride on acute ethanol withdrawal severity in male and female C57BL/6J and DBA/2J mice. Finasteride, a 5α-reductase inhibitor, was found to increase withdrawal severity in female mice but decrease it in male mice, without altering blood ethanol concentrations, ethanol clearance, estradiol, or corticosterone levels. These results suggested sex differences in sensitivity to changes in neurosteroid levels, such as allopregnanolone, during ethanol withdrawal.
