Case Report: Sequential Therapy with Dupilumab and Baricitinib for Severe Alopecia Areata with Atopic Dermatitis in Children

    June 2024 in “ Frontiers in immunology ”
    Huijuan Fang, Zhang Feng-chuan, Weiren Lin, Li Ma, Qingwu Liu, Dingquan Yang
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    TLDR Sequential therapy with dupilumab and baricitinib improved hair regrowth and atopic dermatitis in a child without adverse reactions.
    This case report describes the treatment of an 8-year-old girl with severe alopecia areata (AA) and atopic dermatitis (AD) using sequential therapy with dupilumab and baricitinib. Initially, 6 months of dupilumab led to significant improvement in AD and partial hair regrowth, though some hair was white, and eyebrows were lost. A subsequent 5-month course of baricitinib resulted in further hair regrowth, including eyebrows, with no AD recurrence. The treatment was well-tolerated without adverse reactions, and laboratory parameters remained stable. The report suggests that this combined therapy could be effective for severe AA with AD, but emphasizes the need for larger trials to confirm these findings.
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