Detection of a Second KAP22 Family Member in Sheep and Analysis of Its Genetic Variation and Associations with Selected Wool Fiber Traits

    September 2025 in “ Animals ”
    Lingrong Bai, Huitong Zhou, Jinzhong Tao, Jon G. H. Hickford
    Studysummary This study identified novel genetic variations in the KRTAP22-2 gene among eight sheep breeds but found no association between these genotypes and wool fibre traits, indicating possible species-specific differences compared to goats.
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    Research cited in this study 12

    1. Genetics of Wool and Cashmere Fibre: Progress, Challenges, and Future Research Animals · 2024
    2. Identification of the Keratin-Associated Protein 22-2 Gene in Capra Hircus and Its Association with Cashmere Traits Animals · 2023
    3. Identification of the KAP27-1 Gene in Sheep and Its Effect on Wool Traits New Zealand journal of agricultural research · 2022
    4. Molecular Characterization of Caprine KRTAP13-3 in Liaoning Cashmere Goat in China Journal of Applied Animal Research · 2013
    5. Annotation of Sheep Keratin Intermediate Filament Genes and Their Patterns of Expression Experimental Dermatology · 2011
    6. Identification of the Keratin-Associated Protein 13-3 (KAP13-3) Gene in Sheep Open Journal of Genetics · 2011
    7. Characterization and Expression Analysis of the Hair Keratin Associated Protein KAP26.1 British Journal of Dermatology · 2008
    8. Characterization of Human KAP24.1, A Cuticular Hair Keratin-Associated Protein with Unusual Amino Acid Composition and Repeat Structure ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2007
    9. Biology of the Wool Follicle: An Excursion into a Unique Tissue Interaction System Waiting to Be Rediscovered Experimental Dermatology · 2006
    10. Human KAP Genes: Only Half of It? Extensive Size Polymorphisms in Hair Keratin-Associated Protein Genes ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2005
    11. Complete Sequence of a Hair-Like Intermediate Filament Type II Keratin Gene DNA sequence · 1993
    12. Hair Follicle Differentiation: Expression, Structure, and Evolutionary Conservation of the Hair Type II Keratin Intermediate Filament Gene Family Development · 1992