Nutritional Pharmacology and Mechanistic Insights of Saw Palmetto in Male Endocrine and Prostatic Disorders

    November 2025 in “ Zenodo (CERN European Organization for Nuclear Research) ”
    Xu Jin
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    TLDR Saw Palmetto, combined with Lycopene, L-Arginine, and Astaxanthin, improves male health by balancing hormones, reducing inflammation, and enhancing hair and urinary health without side effects.
    The study explores the use of Saw Palmetto as a botanical intervention for male urogenital and endocrine disorders, focusing on its integration within the Keyora Endocrine–Inflammatory–Prostatic Framework. At a physiological dose, Saw Palmetto partially inhibits 5-α-reductase, reduces inflammatory markers, and enhances mitochondrial bioenergetics. When combined with Lycopene, L-Arginine, and Astaxanthin, it creates a synergistic effect that restores hormonal balance, suppresses chronic inflammation, and improves microvascular oxygenation. Clinical data show benefits such as enhanced hair density, improved urinary flow, and reduced oxidative and inflammatory biomarkers, without adverse endocrine effects. This positions Saw Palmetto as a systems-level modulator for male health, promoting durable physiological coherence.
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