Comparison of Clinical Efficacy of Tofacitinib Versus Methotrexate in Severe Alopecia Areata, Alopecia Totalis, and Alopecia Universalis: A Randomized Controlled Trial

    June 2026 in “ Khyber Journal Of Medical Sciences ”
    Hira Rehman, Ghafoor Ullah, Filza Ajmal … Marwah Rehman
    Studysummary This study found that among adults with severe alopecia areata, alopecia totalis, or alopecia universalis, oral tofacitinib was more effective than methotrexate in reducing hair loss over a 12-week period, though long-term safety and efficacy remain unestablished.
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    Research cited in this study 14

    1. A Study on the Role of Tofacitinib Among Patients Treated with Alopecia Areata Pakistan Journal of Medical and Health Sciences · 2022
    2. The Efficacy and Safety of JAK Inhibitors for Alopecia Areata: A Systematic Review and Meta-Analysis of Prospective Studies Frontiers in pharmacology · 2022
    3. Hair Regrowth Outcomes of Contact Immunotherapy for Patients With Alopecia Areata JAMA Dermatology · 2018
    4. Alopecia Areata: A Review of Disease Pathogenesis British journal of dermatology/British journal of dermatology, Supplement · 2018
    5. Intralesional Betamethasone as a Therapeutic Option for Alopecia Areata Anais Brasileiros de Dermatologia · 2018
    6. An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis Journal of Investigative Dermatology · 2018
    7. Emerging Drugs for Alopecia Areata: JAK Inhibitors Expert opinion on emerging drugs · 2018
    8. An Overview of the Biology of Platelet-Rich Plasma and Microneedling as Potential Treatments for Alopecia Areata Journal of Investigative Dermatology Symposium Proceedings · 2017
    9. Safety and Efficacy of the JAK Inhibitor Tofacitinib Citrate in Patients with Alopecia Areata JCI insight · 2016
    10. Oral Ruxolitinib Induces Hair Regrowth in Patients with Moderate-to-Severe Alopecia Areata JCI insight · 2016
    11. Benefit of Different Concentrations of Intralesional Triamcinolone Acetonide in Alopecia Areata: An Intrasubject Pilot Study Journal of the American Academy of Dermatology · 2015
    12. British Association of Dermatologists’ Guidelines for the Management of Alopecia Areata 2012 British Journal of Dermatology · 2012
    13. Alopecia Areata: An Autoimmune Disease Causing Hair Loss The New England Journal of Medicine · 2012
    14. Alopecia Areata in Korea (1982–1994) The Journal of Dermatology · 1995