An Updated Review of Topical Tretinoin in Dermatology: From Acne and Photoaging to Skin Cancer

The review highlights the efficacy and safety of topical tretinoin in treating various dermatological conditions, particularly acne vulgaris and photoaging, supported by robust data from randomized clinical trials. Tretinoin is effective in reducing acne lesions, improving photoaging signs, and enhancing the efficacy of treatments for conditions like melasma and alopecia areata. It is well-tolerated, with mild side effects, and shows promise in treating other conditions such as acanthosis nigricans and striae distensae. However, more high-quality trials are needed to establish definitive clinical guidelines for its use in less-studied conditions. Despite its long history, research continues to explore new applications and formulations to enhance its tolerability and adherence.