Response to the Letter to the Editor: Androgenetic Alopecia, Drug Safety, and Therapeutic Strategies

    April 2018 in “ Expert Opinion on Drug Safety
    Ion G. Motofei, David L. Rowland
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    TLDR Use finasteride over dutasteride for hair loss; consider topical treatments and weigh risks.
    The authors respond to a letter to the editor regarding drug safety and therapeutic strategies for androgenetic alopecia. They note that androgenetic alopecia is not considered an effective disease, as it has minimal or no impact on body physiology, and that androgens are only partly responsible for hair loss. They caution against procedures that result in androgenic suppression, such as dutasteride and finasteride, due to their associated adverse effects. They suggest that finasteride should be preferred to dutasteride and that oral administration of finasteride for androgenetic alopecia should be reevaluated in favor of topical therapies. They also note that the risk-benefit ratio of finasteride should be considered, as the benefit is related to an esthetic aspect while the risk is related to very real organic adverse effects.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  828 upvotes 5 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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      in Progress Pictures  13 upvotes 1 year ago
      The conversation is about a person's slow progress in treating hair loss using finasteride, microneedling, testosterone replacement therapy, dutasteride, RU58841, and minoxidil. They experienced a significant hair shed after adding dutasteride.
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      community Anyone here going the “natural” route?

      in Scalp Massage  48 upvotes 2 years ago
      People discussing their experiences with natural treatments for hair loss, such as essential oils, deep scalp massages, anti-inflammatory measures, and supplements. Most of the replies suggest that these treatments are not effective and recommend medication such as minoxidil or finasteride instead.

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