Renal Carcinoma Presenting With Adrenocortical Insufficiency Due to a Pituitary Metastasis

    July 1998 in “ Annals of Clinical Biochemistry International Journal of Laboratory Medicine ”
    David Beckett, Rousseau Gama, Jeremy Wright, Gordon A. Ferns
    TLDR A man's adrenal insufficiency was caused by a pituitary tumor linked to kidney cancer.
    A 56-year-old man with a history of hypertension and Horner's syndrome presented with symptoms of lethargy and vomiting, which led to the discovery of hyponatremia and low plasma glucose levels. Initial tests indicated adrenal insufficiency, and he was treated for Addison's disease with hydrocortisone, which initially improved his condition. However, he later developed symptoms such as hair loss, loss of libido, weight gain, and cold intolerance, prompting further evaluation. Tests revealed hypogonadotrophic hypogonadism and secondary hypothyroidism, suggesting pituitary dysfunction. The case highlighted the complexity of diagnosing and managing endocrine disorders, particularly when symptoms overlap with other conditions.
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