The Study of Improvement of Hair Follicle Stem Cells of Rats in Vitro Culture Identification and Differentiation

    December 2016 in “ Chin J Anat Clin ”
    Weibin Du, Renfu Quan, Xuan Zheng, Qiang Li, Guoping Cao, Zhuang Wei, Rongxue Shao
    TLDR Rat hair follicle stem cells can be effectively isolated and used for tissue engineering.
    The study successfully isolated and cultured rat hair follicle stem cells (rHFSCs) from 6 one-week-old SD rats, confirming their identity through high expression of markers like Integrin β1, Integrin α6, and P63. These cells demonstrated strong self-renewal and multipotent differentiation capabilities, particularly in adipogenic and osteogenic differentiation, with notable gene expression and morphological changes. The research laid groundwork for potential applications in tissue engineering and wound healing, though it suggested further optimization of differentiation protocols to improve osteogenic potential.
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