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Did you mean Sprague-Dawley rats?

Glossary Sprague-Dawley rats

albino rats commonly used in laboratory research

Sprague-Dawley rats are a breed of albino rats commonly used in laboratory research due to their docile nature, ease of handling, and well-documented genetic background. They are frequently employed in studies related to toxicology, pharmacology, and various biological and medical research areas, including hair and skin studies, due to their consistent and reproducible responses.

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research Sub-chronic testosterone treatment increases the levels of epithelial sodium channel (ENaC)-α,βandγin the kidney of orchidectomized adult male Sprague–Dawley rats

18 citations , June 2016 in “PeerJ”

In this study, testosterone increased the expression of epithelial sodium channel proteins and mRNAs in rat kidneys, suggesting a potential mechanism for its effect on blood pressure through enhanced sodium reabsorption.

research Hair regenerative activities of flavonoid-rich extract of Equisetum hyemale L. (Equisetaceae) in chemically-induced alopecia in Sprague Dawley rats

1 citations , January 2019 in “Journal of pharmacy & pharmacognosy research”

This study found that a 2.5% flavonoid-rich extract of Equisetum hyemale promoted hair growth in a rat model of chemically-induced alopecia, showing results comparable to 5% minoxidil.

Inhibitory Effects of Pueraria Mirifica Aqueous Extracts on 5α-Reductase and Prostate Histomorphometry in Testosterone-Induced Benign Prostatic Hyperplasia Sprague Dawley Rats

research Inhibitory Effects of Pueraria mirifica Aqueous Extracts on 5α-reductase and Prostate Histomorphometry in Testosterone-induced Benign Prostatic Hyperplasia Sprague Dawley Rats

August 2023 in “Malaysian Journal of Medicine and Health Sciences/Malaysian journal of medicine and health sciences”

This study found that aqueous extract of Pueraria mirifica, when administered to a rat model, significantly reduced prostate weight, prostatic index, and serum dihydrotestosterone levels, while also improving prostate histomorphology, suggesting its potential as an anti-BPH treatment.

Supraphysiological Dose of Testosterone Impairs the Expression and Distribution of Sex Steroid Receptors During Endometrial Receptivity Development in Female Sprague-Dawley Rats

research Supraphysiological Dose of Testosterone Impairs the Expression and Distribution of Sex Steroid Receptors during Endometrial Receptivity Development in Female Sprague–Dawley Rats

September 2024 in “International Journal of Molecular Sciences”

This study found that administering a supraphysiological dose of testosterone to female rats significantly reduced estrogen and progesterone levels, disrupted sex steroid receptor expression, and interfered with the embryonic implantation window, indicating potential implications for androgen-related endometrial conditions.

Systemic Subchronic Toxicity and Comparison of Four Selenium Nutritional Supplements by 90-Day Oral Exposure in Sprague-Dawley Rats

research Systemic subchronic toxicity and comparison of four selenium nutritional supplements by 90-day oral exposure in Sprague-Dawley rats

September 2023 in “Food and chemical toxicology”

In this study on Sprague-Dawley rats, 0.60 mg/kg doses of L-Se-methylselenocysteine and sodium selenite were associated with liver toxicity and reduced sperm motility, while Se-enriched peptides showed no observable adverse effects up to 0.60 mg/kg.

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community Brief summary of new dutasteride study linked to infertility and the limitations/problems with the study

in Finasteride/Dutasteride 34 upvotes 1 year ago

Dutasteride treatment may decrease sperm concentration, but levels remain above WHO recommendations and recover after discontinuation. The study has limitations, including small sample size and lack of pre-treatment sperm data, and does not assess other fertility factors.

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Research

research Sub-chronic testosterone treatment increases the levels of epithelial sodium channel (ENaC)-α,βandγin the kidney of orchidectomized adult male Sprague–Dawley rats

research Hair regenerative activities of flavonoid-rich extract of Equisetum hyemale L. (Equisetaceae) in chemically-induced alopecia in Sprague Dawley rats

research Inhibitory Effects of Pueraria mirifica Aqueous Extracts on 5α-reductase and Prostate Histomorphometry in Testosterone-induced Benign Prostatic Hyperplasia Sprague Dawley Rats

research Supraphysiological Dose of Testosterone Impairs the Expression and Distribution of Sex Steroid Receptors during Endometrial Receptivity Development in Female Sprague–Dawley Rats

research Systemic subchronic toxicity and comparison of four selenium nutritional supplements by 90-day oral exposure in Sprague-Dawley rats

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community Brief summary of new dutasteride study linked to infertility and the limitations/problems with the study

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