Curling of Hair in Two Female Patients Taking Alitretinoin

October 2018 in “ Drug safety - case reports ”

Kim Alting, Florence van Hunsel

alitretinoin chronic hand eczema diffuse alopecia synthetic retinoids hair follicle function thyroid hormones

Studysummary In this report, two women treated with alitretinoin experienced persistent curling of their previously straight hair, suggesting a likely causal link between the medication and hair texture changes.

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Research cited in this study

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research A Case of Repigmentation and Curling of Hair on Acitretin Therapy

17 citations , November 2013 in “Clinical and experimental dermatology”

This case report describes repigmentation and curling of hair in a patient undergoing acitretin therapy.

research Complete Remission of Alopecia Areata Under Treatment of Chronic Hand Eczema with Alitretinoin

8 citations , January 2013 in “European Journal of Dermatology”

This article reviews the use of alitretinoin for corticosteroid-refractory chronic hand eczema and explores its potential therapeutic benefits in other skin conditions, but reports no clinical results.

Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

research Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

115 citations , August 2008 in “The Journal of Clinical Endocrinology & Metabolism”

In this study, T3 and T4 were found to directly influence human hair follicles in vitro, enhancing keratinocyte proliferation, prolonging the hair growth phase, and affecting pigmentation.

research Drug Reactions Affecting Hair: Diagnosis

85 citations , April 2007 in “Dermatologic Clinics”

This article reviews drug-induced hair changes, highlighting that while many drugs are occasionally linked to hair loss, this connection has been conclusively established for only a few, and such hair loss is typically reversible.

research Acquired Progressive Kinking of the Hair

26 citations , October 1999 in “Archives of Dermatology”

This discussion suggests that acquired progressive kinking of hair in androgen-dependent scalp areas may indicate the early stages of androgenetic alopecia with a poor prognosis, but it offers no new clinical findings.

research Unruly Hair

19 citations , October 1985 in “British Journal of Dermatology”

This review proposes a new approach for categorizing and diagnosing unruly hair forms, building on previous literature and clinical experience, without presenting new clinical results.