Secondary Cutis Verticis Gyrata Induced by Long-Term Use of High-Dose Topical Minoxidil

August 2024 in “ Skin Appendage Disorders ”

Juste Baksanskaite, Natalia Caballero Uribe, Ralph M. Trüeb

Cutis Verticis Gyrata topical minoxidil male androgenetic alopecia insulin-like growth factor IGF-1 soft tissue hypertrophy hypertrichosis CVG Rogaine male pattern baldness soft tissue growth excessive hair growth

Studysummary This study presents the first reported case of cutis verticis gyrata resulting from long-term, high-concentration topical minoxidil use for treating male androgenetic alopecia, highlighting a potential link to insulin-like growth factor effects.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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research Serious Complication of Low-Dose Oral Minoxidil for Hair Loss

1 citations , October 2022 in “JAAD case reports”

This report highlights a serious complication associated with low-dose oral minoxidil in treating female androgenetic alopecia, an adverse effect previously thought to be rare and minor.

research Pericardial, Pleural Effusion and Anasarca: A Rare Complication of Low-Dose Oral Minoxidil for Hair Loss

3 citations , August 2022 in “JAAD case reports”

This review discusses the emerging evidence for low-dose oral minoxidil in treating various types of alopecia, without providing new clinical results.

research Does Topical Minoxidil at Concentrations Higher Than 5% Provide Additional Clinical Benefit?

4 citations , July 2022 in “Clinical and Experimental Dermatology”

This review examines the efficacy and safety of using minoxidil at concentrations greater than 5% for androgenetic alopecia but reports no new clinical results, emphasizing a need for further research.

research Minoxidil-Induced Hypertrichosis in a Breastfed Infant

March 2022 in “Journal of The European Academy of Dermatology and Venereology”

research Safety of Low-Dose Oral Minoxidil for Hair Loss: A Multicenter Study of 1404 Patients

39 citations , February 2021 in “Journal of The American Academy of Dermatology”

In this study, low-dose oral minoxidil for hair loss was associated with infrequent systemic adverse effects, and only 1.7% of patients discontinued treatment due to these effects.

Efficacy and Safety of a New 10% Topical Minoxidil Versus 5% Topical Minoxidil and Placebo in the Treatment of Male Androgenetic Alopecia: A Trichoscopic Evaluation

research Efficacy and Safety of a New 10% Topical Minoxidil Versus 5% Topical Minoxidil and Placebo in the Treatment of Male Androgenetic Alopecia: A Trichoscopic Evaluation

14 citations , August 2019 in “Journal of Dermatological Treatment”

This study found that 5% topical minoxidil was moderately more effective at increasing hair regrowth than 10% minoxidil and placebo in men with androgenetic alopecia.

research Further Clinical Evidence for the Effect of IGF-1 on Hair Growth and Alopecia

29 citations , August 2017 in “Skin appendage disorders”

This study found that IGF-1 likely plays a crucial role in regulating hair growth and alopecia, with balding scalp follicles secreting less IGF-1 than nonbalding counterparts.

research Cantú Syndrome Is Caused by Mutations in ABCC9

148 citations , May 2012 in “The American Journal of Human Genetics”

This study identified heterozygous mutations in the ABCC9 gene as the genetic basis of Cantú syndrome, suggesting the syndrome as a new member of potassium channelopathies.

research Minoxidil: Mechanisms of Action on Hair Growth

397 citations , February 2004 in “British Journal of Dermatology”

This article reviews the mechanisms by which minoxidil stimulates hair growth and reports no new clinical findings.

research Pseudoacromegaly Induced by the Long-Term Use of Minoxidil

41 citations , June 2003 in “Journal of The American Academy of Dermatology”

This case report describes a patient who developed pseudoacromegaly from long-term use of high-dose minoxidil, marking the first such documented case.

A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

research A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

269 citations , August 2002 in “Journal of The American Academy of Dermatology”

This study found that 5% topical minoxidil significantly increased hair regrowth and improved psychosocial perceptions of hair loss in men with androgenetic alopecia compared to 2% topical minoxidil and placebo over 48 weeks.

research In the Absence of Streptomycin, Minoxidil Potentiates the Mitogenic Effects of Fetal Calf Serum, Insulin-Like Growth Factor 1, and Platelet-Derived Growth Factor on NIH 3T3 Fibroblasts in a K+ Channel-Dependent Fashion

32 citations , August 1996 in “Journal of Investigative Dermatology”

research Stimulation of Elastin Expression by Minoxidil in Chick Skin Fibroblasts

15 citations , January 1995 in “Archives of Dermatological Research”

This study suggests that minoxidil is a potent stimulator of elastin expression in embryonic skin fibroblasts, primarily affecting elastin mRNA levels, without impacting cell proliferation during the stationary phase.

Sulfation of Minoxidil in Keratinocytes and Hair Follicles and the Stimulatory Effect of Minoxidil on the Biosynthesis of Glycosaminoglycans

research Sulfation of Minoxidil in Keratinocytes and Hair Follicles and the Stimulatory Effect of Minoxidil on the Biosynthesis of Glycosaminoglycans

5 citations , December 1991 in “Annals of the New York Academy of Sciences”

Minoxidil boosts hair growth by undergoing a process in hair follicles and certain skin cells, and by increasing the production of compounds essential for hair growth and maintenance.

research Suppression of Fibroblast Proliferation and Lysyl Hydroxylase Activity by Minoxidil

63 citations , September 1987 in “Journal of Biological Chemistry”

Minoxidil slows fibroblast growth and collagen production, potentially treating keloids, hypertrophic scars, and connective tissue disorders.

research Minoxidil for Severe Hypertension After Failure of Other Hypotensive Drugs

86 citations , September 1977 in “BMJ”

Minoxidil effectively controls blood pressure in severe cases, but has serious side effects and causes hair growth in women.