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    Biological Activity of Novel Progesterone Derivatives Having Bulky Ester Side Chains at C-3

    April 2008 in “ Steroids ”
    Marisa Cabeza, Eugene Bratoeff, Elena Ramírez … Victor Haber Perez
    Studysummary This study found that pregnane derivatives with higher lipophilicity, like compound 9d, had stronger androgen receptor binding and greater antiandrogenic effects in rats, correlating relative binding affinity with log P values.
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    Research cited in this study 2

    1. Recent Advances in the Chemistry and Pharmacological Activity of New Steroidal Antiandrogens and 5α-Reductase Inhibitors Current Medicinal Chemistry · 2005
    2. New 5α-Reductase Inhibitors: In Vitro and In Vivo Effects Steroids · 2005

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    1. Biological Activity of Novel Progesterone Derivatives Having Bulky Ester Side Chains at C-3 Steroids · 2008
    2. New Aromatic Esters of Progesterone as Antiandrogens Journal of Enzyme Inhibition and Medicinal Chemistry · 2004
    3. Synthesis and In Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-Oxo-4-Androstene-17β-Carboxamides as 5α-Reductase Inhibitors and Antiandrogens Journal of Medicinal Chemistry · 1995
    4. Combination of an Antiandrogen and a 5α-Reductase Inhibitor: A Further Step Towards Total Androgen Blockade? Endocrinology · 1991