Testosterone Alters Iron Metabolism and Stimulates Red Blood Cell Production Independently of Dihydrotestosterone

July 2014 in “ American Journal of Physiology-Endocrinology and Metabolism ”

Luke A. Beggs, Joshua F. Yarrow, Christine F. Conover, John R. Meuleman, Darren T. Beck, Matthew P. Morrow, Baiming Zou, Jonathan J. Shuster, Stephen E. Borst

testosterone dihydrotestosterone type II 5α-reductase testosterone-enanthate finasteride red blood cell production iron metabolism hypogonadal erythropoiesis hepcidin ferritin DHT TE Propecia

Studysummary This study found that testosterone-enanthate increased red blood cell production and altered iron homeostasis in older hypogonadal men without being affected by finasteride, indicating these effects do not require type II 5α-reductase enzyme activity.

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Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men With Suppressed Testosterone Production

research Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men With Suppressed Testosterone Production

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This review discusses the role of skeletal muscle in synthesizing bioactive androgens, highlighting that intramuscular androgens may influence muscle via intracrine action, but their precise function remains unclear.

research Anabolic Effects of Testosterone Are Preserved During Inhibition of 5α-Reductase

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In this animal study, administering testosterone alongside a 5α-reductase inhibitor counteracted testosterone's effects on prostate enlargement while preserving its beneficial effects on muscle and bone.

Exogenous Testosterone Alone or with Finasteride Increases Physical Performance, Grip Strength, and Lean Body Mass in Older Men with Low Serum Testosterone

research Exogenous Testosterone Alone or with Finasteride Increases Physical Performance, Grip Strength, and Lean Body Mass in Older Men with Low Serum Testosterone

506 citations , March 2005 in “The Journal of Clinical Endocrinology and Metabolism”

This study found that testosterone therapy improved physical performance and strength in older men with low testosterone over 36 months, whether administered alone or with finasteride.

research Exogenous Testosterone or Testosterone with Finasteride Increases Bone Mineral Density in Older Men with Low Serum Testosterone

417 citations , February 2004 in “The Journal of Clinical Endocrinology and Metabolism”

This study found that testosterone therapy increased bone mineral density in older men with low testosterone, and combining it with finasteride may reduce prostate enlargement associated with testosterone treatment.

research Steroid 5α-Reductases and 3α-Hydroxysteroid Dehydrogenases: Key Enzymes in Androgen Metabolism

115 citations , March 2001 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism”

This article reviews how different 5alpha-reductase and 3alpha-HSD enzymes impact androgen levels and highlights their potential as drug targets for androgen-related diseases, but provides no new experimental findings.