Ephrins Negatively Regulate Cell Proliferation in the Epidermis and Hair Follicle

May 2010 in “ Stem Cells ”

Maria Genander, Johan Holmberg, Jonas Frisén

ephrins Eph receptors hair follicle epidermis ephrin-A2-Fc ephrin-B2-Fc cell proliferation stem cells bulge area regenerative therapies ephrin-A2 ephrin-B2

Studysummary This study reported that disrupting ephrin-Eph interactions in adult mouse skin doubled cell proliferation in the hair follicle and epidermis, suggesting ephrins as negative regulators of proliferation.

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