The efficacy and safety of dutasteride compared with finasteride in treating men with androgenetic alopecia: a systematic review and meta-analysis

    February 2019 in “Clinical Interventions in Aging
    Zhongbao Zhou, Shiqiang Song, Zhenli Gao, Jitao Wu, Jiajia Ma, Yuanshan Cui
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    TLDR Dutasteride more effectively treats hair loss than finasteride, but may increase risk of altered libido.
    This systematic review and meta-analysis compared the efficacy and safety of dutasteride and finasteride in treating men with androgenetic alopecia (AGA). Three randomized controlled trials (RCTs) were included in the study, which analyzed the mean change in total hair count, investigator's assessment of global photographs, panel global photographic assessment, and subjects' assessment. The results showed that dutasteride was more effective than finasteride in increasing total hair count and improving the investigator's and panel global photographic assessments for the vertex and frontal views. However, there was no significant difference in subjects' assessment between the two drugs. In terms of safety, dutasteride was associated with a higher risk of altered libido compared to finasteride.
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      research The clinical applications of five-alpha reductase inhibitors.

       2 citations,  April 2021 in “Canadian Journal of Urology”
      Five-alpha reductase inhibitors, like finasteride and dutasteride, can treat enlarged prostates, improve urination, reduce need for prostate surgery, and lower the risk of prostate cancer, but may increase the risk of higher grade prostate cancer. They can also treat male pattern baldness.