Psoriasis Research: A Comprehensive Review

Psoriasis was described as an inflammatory skin disorder affecting 2-3% of the global population, characterized by irregular epidermal differentiation and hyperproliferation. The pathophysiology involved T-cell activation and migration to the dermis, leading to cytokine release, inflammation, and increased skin cell production. Factors contributing to psoriasis included emotional stress, skin damage, systemic diseases, intestinal issues, and certain medications. Various types of psoriasis, such as plaque, scalp, and nail psoriasis, were identified and diagnosed through clinical methods like skin biopsies. Treatment options aimed to regulate the immune system or normalize keratinocyte differentiation, including topical drugs, systemic agents, phototherapy, and homeopathic approaches, tailored to the type, origin, extent, and severity of the condition.