Addition of Platelet-Rich Plasma to Endorectal Advancement Flap Repair Does Not Enhance Healing of Cryptoglandular Transsphincteric Fistulas

The study investigated the addition of platelet-rich plasma (PRP) to endorectal advancement flap repair in 219 patients with cryptoglandular transsphincteric fistulas. It found no significant difference in healing rates between those treated with PRP and those without, with 73.9% healing in the PRP group compared to 77.1% in the non-PRP group. The long-term recurrence rate was also similar. The study concluded that PRP does not enhance the short-term or long-term outcomes of the surgical repair, despite its theoretical benefits in wound healing.