Efficacy and Safety of Autologous Adipose-Derived Stromal Vascular Fraction Enriched with Platelet-Rich Plasma in Flap Repair of Transsphincteric Cryptoglandular Fistulas

    October 2021 in “ Techniques in Coloproctology ”
    W. R. Schouten, Jeanine Arkenbosch, C. Janneke van der Woude, Annemarie C. de Vries, Hieronymus P. Stevens, Gwenny M. Fuhler, Roy S. Dwarkasing, Oddeke van Ruler, Eelco J. R. de Graaf
    TLDR Using SVF enriched with PRP in surgery for certain fistulas is effective and safe.
    The study evaluated the efficacy and safety of using autologous adipose-derived stromal vascular fraction (SVF) enriched with platelet-rich plasma (PRP) in flap repair for transsphincteric cryptoglandular fistulas. Conducted on 45 patients, the study found that primary fistula healing occurred in 84% of the total population, with a long-term healing rate of 82%. MRI results showed complete closure of the fistula tract in 89.2% of patients. The procedure was generally safe, with only three adverse events reported. The addition of SVF enriched with PRP was deemed feasible and potentially beneficial for improving surgical outcomes.
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