Protease-Activated Receptor-1 (Thrombin Receptor) Is Expressed in Mesenchymal Portions of Human Hair Follicle

September 2003 in “ Journal of Investigative Dermatology ”

Tadashi Anan, Tadashige Sonoda, Yuji Asada, Susumu Takayasu, Sotaro Kurata

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Research cited in this study

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research Identification of clustered cells in human hair follicle responsible for MMP‐9 gelatinolytic activity: consequences for the regulation of hair growth

27 citations , June 2001 in “International Journal of Dermatology”

research Differences in Hair Follicle Dermal Papilla Volume Are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses

231 citations , December 1999 in “Journal of Investigative Dermatology”

Hair follicle size is mainly influenced by the number of cells and extracellular matrix volume, with cell number having a larger impact.

research The mRNA for Protease Nexin-1 is Expressed in Human Dermal Papilla Cells and its Level is Affected by Androgen

27 citations , September 1999 in “Journal of Investigative Dermatology”

Human skin cells contain Protease Nexin-1, and male hormones can decrease its levels, potentially affecting hair growth.

research Message of nexin 1, a serine protease inhibitor, is accumulated in the follicular papilla during anagen of the hair cycle

37 citations , December 1995 in “Journal of Cell Science”

The study identified a 1.3 kb mRNA encoding nexin 1, a serine protease inhibitor, which was found in high quantities in rat follicular papillary cells but not in skin fibroblasts. Nexin 1 can inactivate several growth-modulating serine proteases. In situ hybridization revealed that nexin 1 mRNA accumulated in the follicular papilla cells during the anagen phase of the hair cycle, but was undetectable in keratinocytes or other skin mesenchymal cells. The level of nexin 1 mRNA varied among different rat vibrissa papillary cell lines and correlated with their ability to support follicular reconstitution in vivo. These findings suggested that nexin 1 might play a role in regulating hair follicle growth.

research Distribution of Extracellular Matrix Molecules in Human Hair Follicles

45 citations , December 1991 in “Annals of the New York Academy of Sciences”

ECM molecules are crucial for hair growth and development.

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