Identification of clustered cells in human hair follicle responsible for MMP‐9 gelatinolytic activity: consequences for the regulation of hair growth
June 2001
in “
International Journal of Dermatology
”
Research cited in this study
7 / 7 resultsresearch Expression of retinoid nuclear receptor superfamily members in human hair follicles and its implication in hair growth.
research The Regulatory Biology of the Human Pilosebaceous Unit
Scientists now better understand how human hair growth is controlled, including the roles of specific genes and proteins.
research Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles
EGF makes hair follicles grow longer but stops hair production.
research IL-1 Alpha Inhibits Human Hair Follicle Growth And Hair Fiber Production In Whole-Organ Cultures
IL-1 alpha stops hair follicle growth and hair production.
research Growth factors specifically alter hair follicle cell proliferation and collagenolytic activity alone or in combination
research Human hair growth in vitro
The study successfully demonstrated the maintenance and growth of human hair follicles in vitro for the first time. Human anagen hair follicles were isolated from scalp skin and cultured in supplemented Williams E medium, showing a significant increase in length over 4 days due to keratinized hair shaft production without losing follicle morphology. The in vitro DNA synthesis pattern mirrored in vivo conditions, and keratin synthesis patterns remained unchanged. The model highlighted the negative growth-regulatory effect of TGF-β1 and the depilatory effects of EGF, similar to those observed in vivo in sheep and mice.
research Differences in Human Skin Between the Epidermal Growth Factor Receptor Distribution Detected by EGF Binding and Monoclonal Antibody Recognition
Related Research
4 / 4 results
research The Stem Cell Quiescence and Niche Signaling Is Disturbed in the Hair Follicle of the Hairpoor Mouse, an MUHH Model Mouse
Hair follicle stem cells in hairpoor mice are disrupted, causing hair loss.
research Hair follicle expression of 1,25-dihydroxyvitamin D3 receptors during the murine hair cycle
research Contrasting Localization of c-Myc with Other Myc Superfamily Transcription Factors in the Human Hair Follicle and During the Hair Growth Cycle
Different Myc family proteins are located in various parts of the hair follicle and may affect stem cell behavior.
research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis
VEGF helps hair grow and determines follicle size by increasing blood vessel growth.