Polyphenols as novel treatment options for dermatological diseases: A systematic review of clinical trials
December 2014
in “Journal of Dermatological Treatment”
TLDR Polyphenols may help treat skin conditions like warts, hair loss, acne, and dark spots, but more research is needed.
The 2014 systematic review analyzed 17 clinical trials to evaluate the effectiveness of polyphenol-based treatments in dermatology, with a focus on conditions such as anogenital warts, alopecia, acne vulgaris, hyperpigmentation, and photoaged skin. The trials included a range of 12 to 503 participants and lasted from 4 weeks to 2 years. Green tea polyphenols were supported by high-quality evidence for treating anogenital warts, while other polyphenols showed potential benefits for alopecia, acne, and hyperpigmentation. For example, a study with 43 men demonstrated significant hair growth over 12 months, and another with 60 women showed reduced melanin content over 8 weeks. Adverse events were generally mild, with no serious adverse events reported. However, the review noted limitations such as small sample sizes and short follow-up times and called for more rigorous trials to establish evidence-based guidelines for polyphenol use in dermatology.
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