Polarity signaling ensures epidermal homeostasis by coupling cellular mechanics and genomic integrity

July 2019 in “ Nature Communications ”

Martim Gomes, Soriba Letzian, Michael Saynisch, Sandra Iden

We don't know much about this study yet.

We're maintaining the world's largest resposity of hair loss research. You can help out the community by sending a PDF of this study here . Not sure how to get a study's PDF? You can email the authors of the study.

View this study on nature.com →

Discuss this study in the Community →

Research cited in this study

10 / 10 results

research Stem Cell Dynamics, Migration, and Plasticity During Wound Healing

211 citations , November 2018 in “Nature Cell Biology”

Stem cells help heal skin wounds by moving and changing roles, working with other cells, and needing more research on their activation and behavior.

research Signaling in the Stem Cell Niche: Regulating Cell Fate, Function, and Plasticity

139 citations , August 2018 in “Development”

The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.

research Homeostasis, regeneration and tumour formation in the mammalian epidermis

44 citations , January 2018 in “The International Journal of Developmental Biology”

Stem cells in the skin help with healing and can also lead to cancer.

Essential Role of Polarity Protein Par3 for Epidermal Homeostasis Through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance

research Essential Role of Polarity Protein Par3 for Epidermal Homeostasis Through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance

26 citations , July 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

The protein Par3 is crucial for healthy skin, affecting the skin barrier, cell differentiation, and stem cell maintenance.

research Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis

242 citations , February 2016 in “Science”

Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.

research Atypical Protein Kinase C Isoform, aPKCλ, Is Essential for Maintaining Hair Follicle Stem Cell Quiescence

24 citations , June 2015 in “Journal of Investigative Dermatology”

aPKCλ is crucial for keeping hair follicle stem cells inactive and maintaining normal hair growth.

research Hairy Tale of Signaling in Hair Follicle Development and Cycling

161 citations , August 2012 in “Seminars in cell & developmental biology”

Hair growth and development are controlled by specific signaling pathways.

research Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration

305 citations , June 2012 in “Nature”

Hair regeneration needs dynamic cell behavior and mesenchyme presence for stem cell activation.

research Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin

1039 citations , February 2009 in “Nature Reviews Molecular Cell Biology”

Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.

research Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells

835 citations , October 2008 in “Nature Genetics”

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.