Loss of Stem Cells Correlates with Premature Aging in Animal Study, Penn Researchers Find

July 2007 in “ Cancer biology & therapy ”

hair loss hair graying stem cells ATR gene DNA damage response premature aging tissue renewal

Studysummary In this study, researchers found that deleting the ATR gene in adult mice led to signs of premature aging and reduced capacity for tissue renewal.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer ·

Read the full study on tandfonline.com →

Discuss this study in the Community →

Similar research 5

Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss Cell Stem Cell · 2007
Editorial: Hair Follicle Stem Cell Regeneration in Aging Frontiers in Cell and Developmental Biology · 2021
Hair Graying as an Evolutionary Checkpoint Against Malignancy: A Stem Cell Perspective Stem Cell Reviews and Reports · 2026
Advanced Age Impairs Self-Renewal and Biases Fate Choice of Hair Follicle Dermal Stem Cells Journal of Investigative Dermatology · 2018
Spatiotemporal Atlas Resolves the Mesenchymal-Epithelial Stem Cell Axis Governing Human Hair Follicle Aging and Pathology bioRxiv (Cold Spring Harbor Laboratory) · 2026

Related Community Posts Join

6 / 1000+ results

community Hair growth stimulated by allogenic adipose-derived stem cells supplemented with ATP in a mouse model of dihydrotestosterone-induced androgenetic alopecia

41 upvotes 1 year ago

Adipose-derived stem cells with ATP improved hair regrowth in male and female mice with androgenetic alopecia. The most effective treatments were low dose stem cells with ATP for males and medium dose stem cells with non-liposomal ATP for females.

community It’s all about the stem cells…

53 upvotes 4 years ago

Hair loss is linked to the loss of stem cells in hair follicles, and potential treatments include gene editing and microneedling. Discussions also mention using Minoxidil, finasteride, and dermarolling to improve hair growth.

community (/r/science X-post): Stress may turn your hair grey. The appearance of grey hairs after periods of stress or skin damage could be the result of depletion of stem cells from the base of the hair follicle, according to a new study : science

4 upvotes 13 years ago

Stress can cause hair to turn grey due to stem cell depletion at the hair follicle base. Treatments discussed include Minoxidil, finasteride, and RU58841 for hair loss.

community Fun thought experiment about halting hair loss permamently

59 upvotes 2 years ago

A user proposed genetically engineering scalp stem cells to stop androgen receptors from causing hair loss. Others discussed the feasibility, existing research, and potential issues with this approach, including targeting the correct cells and unintended effects.

community Cell senescence-targeted treatment for hair loss, has anyone tried any products/enzymes etc. that use this theory

5 upvotes 1 year ago

DHT causes hair loss by driving cells into senescence, and a polyphenol in black chokeberry may reverse this. A product using this theory is being considered for use alongside finasteride, minoxidil, and microneedling.

community Researchers working on ways to regenerate lost hair from stem cells identified a recipe for normal hair regeneration in the lab. “A method for cyclical regeneration of hair follicles from hair follicle stem cells and will help make hair follicle regeneration therapy a reality in the near future.”

263 upvotes 5 years ago

Hair loss treatments like finasteride, minoxidil, and hair transplants have side effects and limitations. There is hope for future advancements in stem cell therapy and hair follicle regeneration, though skepticism about their effectiveness and timeline persists.