Plasma Levels of C19 Steroid Glucuronides in Pre-Menopausal Women with Non-Classical Congenital Adrenal Hyperplasia
TLDR Women with non-classical congenital adrenal hyperplasia have higher levels of certain steroids, which can be reduced by treatment.
The study measured plasma levels of 3α-diolG, ADTG, and DHTG in 15 symptomatic and 3 asymptomatic women with non-classical congenital adrenal hyperplasia (NC-CAH), 5 heterozygote carriers, and 18 normal women. Baseline levels of these glucuronides were significantly higher in symptomatic patients. Chronic glucocorticoid therapy led to an 80% suppression of these glucuronides, indicating its effectiveness. The study concluded that plasma levels of these glucuronides are not related to hirsutism or body weight but reflect adrenal contribution to circulating androgens. The heterozygosity of NC-CAH did not show an intermediate steroid profile, and the glucuronides likely originate from adrenal precursors in non-obese women.
