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GlossaryNon-Classical Adrenal Hyperplasia (NC-CAH)

partial enzyme deficiency causing excess androgen production

Non-Classical Adrenal Hyperplasia (NCAH) is a milder form of congenital adrenal hyperplasia that typically presents later in life, often during adolescence or adulthood. It is caused by a partial deficiency in the enzyme 21-hydroxylase, leading to an overproduction of androgens (male hormones). Symptoms can include irregular menstrual cycles, excessive hair growth (hirsutism), and acne in females, while males may experience early signs of puberty.

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research Polycystic Ovary Syndrome and NC-CAH: Distinct Characteristics and Common Findings. A Systematic Review

32 citations , June 2019 in “Frontiers in Endocrinology”

Polycystic Ovary Syndrome (PCOS) is common in women with conditions like anovulation, hirsutism, hair loss, and type 2 diabetes, and it can lead to health risks like heart disease, obesity, insulin resistance, and depression. Non-Classic Congenital Adrenal Hyperplasia (NC-CAH) is also discussed.

research Functional Evaluation of Novel CYP21A2 Variants: Expanding the Genetic Basis of Non-Classic Congenital Adrenal Hyperplasia

October 2024 in “Journal of the Endocrine Society”

Certain genetic variants impair enzyme activity, contributing to non-classic congenital adrenal hyperplasia.

research Functional Evaluation of Novel CYP21A2 Variants: Expanding the Genetic Basis of Non-Classic CAH

October 2024 in “Journal of the Endocrine Society”

Certain genetic variants reduce enzyme activity, contributing to non-classic congenital adrenal hyperplasia.

research Genetic Screening of Non-Classic CAH Females with Hyperandrogenemia Identifies a Novel CYP11B1 Gene Mutation

April 2016 in “Hormones”

A new mutation in the CYP11B1 gene was found in a woman with mild hyperandrogenemia, a rare cause of non-classic congenital adrenal hyperplasia.

research The Androgen Excess and PCOS Society Criteria for the Polycystic Ovary Syndrome: The Complete Task Force Report

1540 citations , October 2008 in “Fertility and Sterility”

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

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community What does mometasone furoate do for hair loss??

in Research/Science 3 upvotes 3 years ago

Mometasone Furoate Topical Solution 0.1% is used for hair loss, applied after showering and massaged into the damp scalp. The user is seeking information on its effectiveness for hair loss.

community Since there is so much hype for cosmeRNA and HMI-115...

in Chat 46 upvotes 2 years ago

Exploring different treatments for hair loss, such as cosmeRNA and HMI-115 which are small interference messenger RNA that inhibits the DHT receptor and an antibody that binds to the prolactin (PRL) receptor respectively; and researching mechanism and environment of hyperresponders.

community 1 year of 1mg finasteride a day

in Progress Pictures 306 upvotes 4 weeks ago

The user has been taking 1mg of finasteride daily for a year, maintaining hair density without regrowth. They are considering oral minoxidil for regrowth, avoiding topical minoxidil due to its toxicity to cats, despite concerns about heart side effects.

community Result - 5 months of topical minoxidil

in Progress Pictures 7390 upvotes 2 months ago

A 37-year-old man achieved significant hair regrowth in five months using topical minoxidil 5%, rosemary oil massages, and Nizoral 2% shampoo. His impressive results led to disbelief and admiration, with some attributing his success to being a "hyper responder."

community Is Trump no longer on finasteride?

in Finasteride/Dutasteride 258 upvotes 6 months ago

Trump's health report omits finasteride, sparking speculation about whether he stopped using it or switched treatments. Some believe he might not prioritize hair maintenance anymore.

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