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GlossaryNon-Classical Adrenal Hyperplasia (NC-CAH)

partial enzyme deficiency causing excess androgen production

Non-Classical Adrenal Hyperplasia (NCAH) is a milder form of congenital adrenal hyperplasia that typically presents later in life, often during adolescence or adulthood. It is caused by a partial deficiency in the enzyme 21-hydroxylase, leading to an overproduction of androgens (male hormones). Symptoms can include irregular menstrual cycles, excessive hair growth (hirsutism), and acne in females, while males may experience early signs of puberty.

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research Mixed Form of Hirsutism in Adolescent Females and Laser Therapy

7 citations, May 2014 in “Iranian Red Crescent medical journal”

Laser hair removal is effective for hirsutism when combined with treatment for the underlying causes.

research Cardiometabolic Risk Factors in Women with Non-Classic Congenital Adrenal Hyperplasia

2 citations, September 2019 in “Acta Cardiologica”

Women with non-classic congenital adrenal hyperplasia have higher risk for heart and metabolic problems.

research Influence of Genotype and Hyperandrogenism on Sexual Function in Women With Congenital Adrenal Hyperplasia

11 citations, August 2019 in “The Journal of Sexual Medicine”

Women with nonclassic congenital adrenal hyperplasia experience more sexual dysfunction and distress.

research Polycystic Ovary Syndrome and NC-CAH: Distinct Characteristics and Common Findings. A Systematic Review

32 citations, June 2019 in “Frontiers in Endocrinology”

Polycystic Ovary Syndrome (PCOS) is common in women with conditions like anovulation, hirsutism, hair loss, and type 2 diabetes, and it can lead to health risks like heart disease, obesity, insulin resistance, and depression. Non-Classic Congenital Adrenal Hyperplasia (NC-CAH) is also discussed.

research Genetic Screening of Non-Classic CAH Females with Hyperandrogenemia Identifies a Novel CYP11B1 Gene Mutation

April 2016 in “Hormones”

A new mutation in the CYP11B1 gene was found in a woman with mild hyperandrogenemia, a rare cause of non-classic congenital adrenal hyperplasia.

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community What does mometasone furoate do for hair loss??

in Research/Science 3 upvotes 2 years ago

Mometasone Furoate Topical Solution 0.1% is used for hair loss, applied after showering and massaged into the damp scalp. The user is seeking information on its effectiveness for hair loss.

community Since there is so much hype for cosmeRNA and HMI-115...

in Chat 45 upvotes 1 year ago

Exploring different treatments for hair loss, such as cosmeRNA and HMI-115 which are small interference messenger RNA that inhibits the DHT receptor and an antibody that binds to the prolactin (PRL) receptor respectively; and researching mechanism and environment of hyperresponders.