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    The Postnatal Offspring of Finasteride-Treated Male Rats Shows Hyperglycemia, Elevated Hepatic Glycogen Storage, and Altered GLUT2, IR, and AR Expression in the Liver

    Paulina Kur, Agnieszka Kolasa, Marta Grabowska … Barbara Wiszniewska
    Studysummary This study suggests that finasteride treatment in male rats can lead to changes in liver carbohydrate metabolism and may result in metabolic disruptions and liver steatosis in their offspring.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 7

    1. Antioxidant Enzyme Expression of mRNA and Protein in the Epididymis of Finasteride-Treated Male Rat Offspring During Postnatal Development Archives of Medical Science · 2017
    2. Androgen Levels and Apoptosis in the Testis During Postnatal Development of Finasteride-Treated Male Rat Offspring Folia Histochemica Et Cytobiologica · 2015
    3. 5α-Reductase Type 1 Deficiency or Inhibition Predisposes to Insulin Resistance, Hepatic Steatosis, and Liver Fibrosis in Rodents Diabetes · 2014
    4. DHT Deficiency Perturbs the Integrity of the Rat Seminiferous Epithelium by Disrupting Tight and Adherens Junctions Folia Histochemica et Cytobiologica · 2011
    5. The Expression of Inducible Nitric Oxide Synthase (iNOS) in the Testis and Epididymis of Rats with a Dihydrotestosterone (DHT) Deficiency Cellular & Molecular Biology Letters · 2009
    6. Natural Variability and the Influence of Concurrent Control Values on the Detection and Interpretation of Low-Dose or Weak Endocrine Toxicities Environmental Health Perspectives · 2004
    7. The Effect of Finasteride in Men with Benign Prostatic Hyperplasia The New England Journal of Medicine · 1992

    Related research 1

    1. Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men The Journal of Clinical Endocrinology and Metabolism · 1992