TLDR CGRP-IR axons may help maintain and renew tissues.
The study examined the distribution of calcitonin-gene-related peptide (CGRP) immunoreactivity in the peripheral tissues of rats, focusing on its potential nociceptive roles. CGRP-IR was found in small- and medium-diameter sensory ganglion cells, with axons innervating various tissues, including skin, oral epithelium, and deep somatic tissues. In the skin, CGRP-IR axons were associated with dermal blood vessels, sweat glands, and nerve endings, while in deep tissues, they were linked to vasculature and motor end plates. The study suggested that CGRP-IR axons might play a role in tissue maintenance and renewal rather than primarily in nociception.
110 citations
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