Pediatric Adrenocortical Carcinoma Complicated by Uric Acid Nephrolithiasis: A Unique Case Report

This case report describes a rare instance of a 5-year-old boy with adrenocortical carcinoma (ACC) who developed uric acid nephrolithiasis. The child presented with symptoms of Cushing’s syndrome and was found to have a large adrenal mass and kidney stones. Post-surgery, with glucocorticoid therapy, his symptoms and hormone levels normalized, and a four-year follow-up showed no recurrence of ACC or kidney stones. The case highlights the importance of thorough endocrine and metabolic evaluations in managing pediatric ACC and suggests that conservative management can lead to favorable outcomes. Despite the absence of TP53 mutations, comprehensive genetic testing is recommended due to the complex genetic landscape of ACC.