Aromatase Inhibitors Induce Male Pattern Hair Loss in Women

May 2013 in “ Annals of Oncology ”

A. M. Rossi, Alberto Orso Maria Iorio, Elisabetta Scali, Maria Caterina Fortuna, E. Mari, Cristina Maxia, Marianna Alessandra Gerardi, M. Framarino, Marta Carlesimo

aromatase inhibitors male pattern hair loss hormone receptor-positive breast cancer androgenetic alopecia 5α-reductase testosterone DHT frontal hairline recession parietal hairline recession diffuse hair loss pseudo male pattern androgenetic alopecia AIs male pattern baldness FAGA dihydrotestosterone

Studysummary This study observed that aromatase inhibitors caused hair loss in menopausal women with breast cancer, mimicking male pattern baldness rather than female androgenetic alopecia.

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Research cited in this study

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research Gene-Wide Association Study Between the Aromatase Gene (CYP19A1) and Female Pattern Hair Loss

77 citations , April 2009 in “British Journal of Dermatology”

In this study, genetic variation in the CYP19A1 gene, particularly the common rs4646 C allele, was associated with an increased risk of female pattern hair loss, especially in women under 40.

research Androgenetic Alopecia in Women

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This article reviews androgenetic alopecia in women, highlighting diagnosis criteria and noting that topical minoxidil is currently the only proven treatment for hair growth; it reports no clinical trial findings.

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226 citations , September 2001 in “Journal of The American Academy of Dermatology”

Hair loss in women is genetic, diagnosed by examination and biopsy, and treated with minoxidil, finasteride, or transplantation.

research Classification of the Types of Androgenetic Alopecia (Common Baldness) Occurring in the Female Sex

666 citations , September 1977 in “British Journal of Dermatology”

This article presents a classification system for stages of female-pattern androgenetic alopecia to aid early diagnosis and mentions existing systems for rare male-pattern cases, but reports no new clinical results.