Oxidative Stress and Skin Diseases: The Role of Lipid Peroxidation

May 2025 in “ Antioxidants ”

Federica Li Pomi, Luca Gammeri, Francesco Borgia, Mario Di Gioacchino, Sebastiano Gangemi

lipid peroxidation malondialdehyde 4-hydroxynonenal alopecia oxidative stress inflammation photodynamic therapy psoriasis vitiligo LPO MDA 4-HNE

TLDR Lipid peroxidation worsens skin diseases but may help treat cancer.

The document examines the role of lipid peroxidation (LPO) and its products, such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), in various skin diseases, including psoriasis, vitiligo, and alopecia areata (AA). LPO contributes to inflammation and oxidative stress, exacerbating conditions like psoriasis by promoting pro-inflammatory cytokines and keratinocyte proliferation. In AA, increased reactive oxygen species and LPO products are linked to hair follicle damage and hair loss. Elevated LPO markers correlate with disease severity in these conditions. The study suggests that targeting LPO could offer therapeutic benefits, particularly in managing oxidative damage and inflammation in skin diseases.

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