Oral Treatment of Keratinizing Disorders of Skin and Mucous Membranes With Etretinate

February 1982 in “ Archives of dermatology ”

G. Mahrle

etretinate aromatic retinoid psoriasis lichen planus keratosis follicularis erythrodermic psoriasis pustular psoriasis psoriasis vulgaris palmoplantar psoriasis leukoplakia cheilitis hair loss Tigason retinoid skin disorders mucous membrane disorders

Studysummary This study found that oral etretinate improved skin conditions like erythrodermic and pustular psoriasis, although less so for psoriasis vulgaris and lichen planus, with notable side effects including cheilitis and mucous membrane dryness. Our plain-language summary of this paper — not a Tressless recommendation.

This study examined the effects of the aromatic retinoid etretinate on 113 patients with various skin and mucous membrane disorders, including psoriasis, lichen planus, and keratosis follicularis. Patients received 25 to 100 mg/day of oral etretinate for up to 30 months. The best responses were observed in patients with erythrodermic psoriasis, pustular psoriasis, and keratosis follicularis, while those with psoriasis vulgaris, palmoplantar psoriasis, and lichen planus showed less impressive improvements. Mucous membrane lesions of lichen planus and leukoplakia showed only moderate improvement. Notable adverse reactions included cheilitis (70%), dryness of the mucous membranes (27%), and hair loss (27%).

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Research cited in this study

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research Oral Treatment of Severe Psoriasis With a New Aromatic Retinoid (Ro 10-9359)

12 citations , October 1978 in “PubMed”

This study found that the aromatic retinoic acid derivative Ro 10-9359 provided excellent results in 64% of severe psoriasis patients, especially in those with erythrodermic and pustular types, though relapses and side effects were noted.

research Treatment of Psoriasis Vulgaris with a New Retinoic Acid Derivative Ro 10-9359

39 citations , January 1977 in “Dermatology”

This study found that the retinoic acid derivative Ro 10-9359 cleared psoriasis lesions in over half of the patients, but most experienced side effects, including skin issues and altered liver enzyme levels.