Olink Proteomics Analysis of Scalp Psoriasis Reveals a Cytokine Storm Inflammatory Mainly Related to Bacterial-Derived Antigens

This study used Olink high-throughput proteomics to analyze scalp psoriasis (SP) and identified 34 differentially expressed proteins (DEPs) in lesional compared to non-lesional skin. The results highlighted a significant inflammatory response involving Th1, IL-12/IL-23, and Th17 immune signaling pathways. Additionally, the study found dysregulation in the symbiotic relationship with bacteria, suggesting that the cytokine storm in SP lesions is primarily related to bacterial-derived antigens.