Olink Proteomics Analysis of Scalp Psoriasis Reveals a Cytokine Storm Inflammatory Mainly Related to Bacterial-Derived Antigens

July 2025

Lili Fang, Wei Chen, Ningning Shen, Qiang Dong

Olink proteomics scalp psoriasis cytokine storm Th1 IL-12 IL-23 Th17 immune signaling pathways bacterial-derived antigens

Studysummary Using high-throughput proteomics, this study identified 34 differentially expressed proteins in the lesional skin of adults with scalp psoriasis, suggesting a cytokine storm response linked to bacterial antigens.

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This study used Olink high-throughput proteomics to analyze scalp psoriasis (SP) and identified 34 differentially expressed proteins (DEPs) in lesional compared to non-lesional skin. The results highlighted a significant inflammatory response involving Th1, IL-12/IL-23, and Th17 immune signaling pathways. Additionally, the study found dysregulation in the symbiotic relationship with bacteria, suggesting that the cytokine storm in SP lesions is primarily related to bacterial-derived antigens.

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research Comparative Analysis of Scalp and Gut Microbiome in Androgenetic Alopecia: A Korean Cross-Sectional Study

December 2022 in “Frontiers in Microbiology”

This study found that individuals with androgenetic alopecia had higher scalp microbiome diversity and more complex scalp-gut microbiome networks than those without, suggesting a link between skin-gut microorganisms and hair loss development.