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    Neutralization of IL-8 Prevents Dermatologic Adverse Events Associated with Epidermal Growth Factor Receptor Inhibition

    June 2012 in “ PLoS ONE
    Nannie Bangsgaard, Mischa Houtkamp, Danita H. Schuurhuis … Lone Skov
    Studysummary This study found that locally injected zalutumumab in healthy volunteers induced a papulopustular rash similar to systemic EGFR inhibitors, and that IL-8 inhibition reduced this dermatological side effect.
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    Research cited in this study 3

    1. Tumor Necrosis Factor-Alpha and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice Cancer Research · 2009
    2. Immunolocalization of Epidermal Growth Factor Receptors in Normal Developing Human Skin Journal of Investigative Dermatology · 1990
    3. Comparison of Epidermal Growth Factor Binding and Receptor Distribution in Normal Human Epidermis and Epidermal Appendages Journal of Investigative Dermatology · 1984