Pituitary Effects of Metformin in Men With Early-Onset Androgenic Alopecia

May 2022 in “ The Journal of Clinical Pharmacology ”

Robert Krysiak, Karolina Kowalcze, Bogusław Okopień

metformin pituitary hormone androgenic alopecia luteinizing hormone follicle-stimulating hormone insulin sensitivity glycated hemoglobin glucose homeostasis gonadotroph hyperplasia testicular changes LH FSH blood sugar control prediabetes

Studysummary This study suggests that metformin has a stronger impact on gonadotroph hormone levels in men with early-onset androgenic alopecia compared to those with normal hair growth.

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research Impaired Metabolic Effects of Metformin in Men with Early-Onset Androgenic Alopecia

4 citations , December 2021 in “Pharmacological Reports”

This study found that metformin's metabolic benefits, such as reducing fat content and improving insulin sensitivity, were less pronounced in men with early-onset androgenic alopecia compared to those with normal hair growth, possibly due to differences in systemic inflammation and vitamin D status.

research Gynecologic and Andrologic Dermatology and the Metabolic Syndrome

14 citations , September 2017 in “Clinics in Dermatology”

This study highlights that lower testosterone in men and higher testosterone in women are linked to increased risks of metabolic syndrome and type 2 diabetes, with associated skin diseases indicating potential cardiovascular complications.

research Alopecia and the Metabolic Syndrome

30 citations , September 2017 in “Clinics in Dermatology”

This review explores the relationship between androgenetic alopecia and metabolic syndrome, suggesting an association that supports considering cardiovascular risk assessments in patients with this type of hair loss.

research Does a Male Polycystic Ovarian Syndrome Equivalent Exist?

28 citations , July 2017 in “Journal of Endocrinological Investigation”

This study suggests that early onset androgenetic alopecia in men may indicate a male PCOS equivalent, possibly leading to higher risks of metabolic and cardiovascular disorders later in life.

research Polycystic Ovary Syndrome in Men

8 citations , April 2017 in “Medical Hypotheses”

Men with early balding may have hormonal imbalances similar to women with PCOS and could benefit from similar treatments.

research Androgenetic Alopecia: A Review

153 citations , March 2017 in “Endocrine”

This review examines recent advances in understanding the pathophysiology and molecular mechanisms of androgenetic alopecia, highlighting two major genetic risk loci, but does not report new clinical findings.

research A Comparison of the Hormonal Profile of Early Androgenetic Alopecia in Men With the Phenotypic Equivalent of Polycystic Ovarian Syndrome in Women

47 citations , June 2016 in “JAMA Dermatology”

This study suggests men with early androgenetic alopecia might have hormonal profiles similar to women with polycystic ovarian syndrome, potentially indicating risk for related health complications.