Mechanical Stimulation of Human Hair Follicle Outer Root Sheath Cultures Activates Adjacent Sensory Neurons

    October 2023 in “ Science advances ”
    Julià Agramunt, Brenna Parke, Sergio Mena … Claire A. Higgins
    Studysummary In this study, researchers demonstrated that human hair follicle outer root sheath cells release ATP, serotonin, and histamine in response to mechanical stimulation, which subsequently activates surrounding sensory neurons.
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    Research cited in this study 8

    1. Hyperactivation of Sympathetic Nerves Drives Depletion of Melanocyte Stem Cells Nature · 2020
    2. The Hair Follicle: An Underutilized Source of Cells and Materials for Regenerative Medicine ACS biomaterials science & engineering · 2017
    3. The Structure and Organization of Lanceolate Mechanosensory Complexes at Mouse Hair Follicles eLife · 2014
    4. The Functional Organization of Cutaneous Low-Threshold Mechanosensory Neurons Cell · 2011
    5. KCNQ4 K+ Channels Tune Mechanoreceptors for Normal Touch Sensation in Mouse and Man Nature Neuroscience · 2011
    6. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011
    7. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    8. Differential Epithelial Outgrowth of Plucked and Microdissected Human Hair Follicles in Explant Culture Archives of Dermatological Research · 1996

    Related research 4

    1. TRPV3 Gain-of-Function Mutation Impairs Differentiation of Hair Follicle Inner Root Sheath ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2019
    2. Expression of the Bcl-2 Proto-Oncogene in the Cycling Adult Mouse Hair Follicle Journal of Investigative Dermatology · 1994
    3. Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1994
    4. Outer Root Sheath Keratinization in Anagen and Catagen of the Mammalian Hair Follicle: A Seventh Distinct Type of Keratinization in the Hair Follicle - Trichilemmal Keratinization PubMed · 1981