Network Meta-Analysis of FDA-Approved JAK Inhibitors for Alopecia Areata With at Least 50% Hair Loss Per SALT Score

    September 2025 in “ Journal of the American Academy of Dermatology ”
    Mark Lebwohl, Eric D. Collins, Yan Teng, Warren Stevens, Victoria Barghout, Asif Shaikh, James V. Cassella, Thomas J. Ferro
    TLDR Some JAK inhibitors are effective for significant hair regrowth in alopecia areata.
    This network meta-analysis evaluated the efficacy of FDA-approved JAK inhibitors for treating alopecia areata (AA) with at least 50% hair loss, as measured by the Severity of Alopecia Tool (SALT) score. The study compared different JAK inhibitors to determine their effectiveness in promoting hair regrowth in patients with significant hair loss due to AA. The analysis provides insights into the relative performance of these treatments, aiding in the selection of the most effective therapeutic option for patients suffering from this condition.
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