Efficacy of Neutral Electrolyzed Water vs. Common Topical Antiseptics in the Healing of Full-Thickness Burn: Preclinical Trial in a Mouse Model

    October 2024 in “ Biomedical Reports ”
    Iván Delgado‐Enciso, Nomely S. Aurelien-Cabezas, Carmen Meza‐Robles, Mireya Walle‐Guillen, Gustavo A. Hernández‐Fuentes, Ariana Cabrera‐Licona, Alejandra E. Hernández-Rangel, Marina Delgado‐Machuca, Alejandrina Rodríguez‐Hernández, Oscar F. Beas-Guzmán, Citlaly Cardenas‐Aguilar, Iram P. Rodríguez‐Sánchez, Margarita L. Martínez‐Fierro, Lic. Daniel Chaviano Conesa, B.A. Paz-Michel
    Studysummary In this study, BALB/c mice with burn injuries treated with SES-low or SES-low combined with a gel showed better wound healing and organization compared to placebo and common treatments like silver sulfadiazine, highlighting SES-low's effectiveness in promoting favorable healing outcomes. Our plain-language summary of this paper — not a Tressless recommendation.
    This study evaluated the efficacy of superoxidized electrolyzed solution (SES) in healing full-thickness burns in a mouse model, using 252 BALB/c mice. SES, particularly at low concentration (SES-low) and in combination with a gel (SES-low + G), significantly improved wound healing compared to common antiseptics like nitrofurazone and silver sulfadiazine. SES-low showed better wound closure, reduced inflammation, and more organized collagen deposition. By day 32, all treatments achieved wound closure, but SES-low was the most effective in promoting favorable and organized healing. The study suggests SES treatments may enhance burn wound healing due to their anti-inflammatory properties and ability to modulate immune responses. Further research is needed to optimize its use in clinical settings.
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