Nestin Is Expressed in HMB-45 Negative Melanoma Cells in Dermal Parts of Nodular Melanoma

    April 2010 in “ The Journal of Dermatology ”
    Maho Kanoh, Yasuyuki Amoh, Kenichi Tanabe, Hideki Maejima, Hiroshi Takasu, Kensei Katsuoka
    TLDR Nestin helps identify certain melanoma cells in nodular melanoma.
    The study investigated the expression of nestin, a marker of neural and hair follicle stem cells, in melanoma. It was found that nestin immunoreactivity was present in HMB-45-negative melanoma cells in all five cases of amelanotic nodular melanomas and in the dermal parts of seven out of 10 cases of melanotic nodular melanomas. Notably, nestin was expressed in the dermal parts of all 10 cases of HMB-45-negative amelanotic and melanotic nodular melanomas. Conversely, nestin expression was negative in 10 out of 12 cases of superficial spreading melanoma. These findings suggested that nestin served as an important marker for identifying HMB-45-negative melanoma cells in the dermal regions of nodular melanoma patients.
    Discuss this study in the Community →

    Research cited in this study

    9 / 9 results

    Related Community Posts Join

    4 / 4 results

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  140 upvotes 1 year ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

      community One full year progress on fin + min

      in Progress Pictures  517 upvotes 2 years ago
      A user shared their one-year progress using finasteride and minoxidil for hair loss, showing significant improvement. They also mentioned using the medication inconsistently and considering changes to their shampoo routine.

      community Please explain this Minoxidil phenomena

      in Minoxidil  60 upvotes 2 years ago
      The post discusses the difference in effects of Minoxidil (Min) on scalp and facial hair. The user questions why Min-induced hair growth on the scalp is temporary, while facial hair growth seems permanent, even after stopping Min. They propose theories, including different Min mechanisms on body and facial hair, the role of DHT, and the possibility of not achieving fully terminal hair. The responses include personal experiences and theories about Min's effects on hair growth.

      community New Treatments, and a Huge Group Buy with Lots of Research

      in Research/Science  109 upvotes 2 years ago
      A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

    Related Research

    1 / 1 results