Formation of a Regular Neo-Epidermis by Cultured Human Outer Root Sheath Cells Grafted on Nude Mice
April 1995
in “
Transplantation
”
Studysummary This study suggests that human outer root sheath cells are suitable for skin replacement, as they can form a stratified epithelium similar to normal epidermis in organotypic cultures.
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The study demonstrated that cultured human outer root sheath cells, when grafted onto nude mice, formed a stratified epithelium similar to normal epidermis. These cells expressed typical epidermal differentiation markers, such as suprabasal keratins 1 and 10, involucrin, filaggrin, and basement membrane components like collagen type IV and laminin. The findings suggested that outer root sheath cells could serve as a viable and advantageous source for skin replacement, offering a promising alternative to interfollicular keratinocytes in epidermal regeneration.
