Minoxidil Sulfotransferase Enzymatical Activity in Plants: A Novel Paradigm in Increasing Minoxidil Response in Androgenetic Alopecia
August 2023
in “Journal of Cosmetic Dermatology”
TLDR Some plants like spinach, broccoli, and matcha may boost the effectiveness of the hair growth drug minoxidil.
The study investigated the potential of botanical sulfotransferase enzymes to enhance the response to minoxidil, a hair growth drug, by increasing the levels of minoxidil sulfotransferase enzyme (SULT1A1). This enzyme converts minoxidil to its bioactive form, promoting hair growth. Out of 10 plants tested, seven, including spinach, broccoli, and matcha powder, showed significant enzyme activity towards minoxidil. These extracts could potentially increase minoxidil's effectiveness in individuals with varying SULT1A1 activity in their hair follicles. However, the study had limitations, such as the small number of extracts tested and the use of a radiometric assay, which may have affected result accuracy. This is the first study to characterize naturally occurring minoxidil sulfotransferase enzymes in plants.
View this study on onlinelibrary.wiley.com →
Cited in this study
research Low-Dose Oral Minoxidil Improves Hair Density in Traction Alopecia
research The Role of Paracellular Transport in the Intestinal Absorption and Biopharmaceutical Characterization of Minoxidil
research Coming full circle (almost): Low dose oral minoxidil for alopecia
Low-dose oral minoxidil is an effective and safe treatment for hair loss.
research Sulfotransferase activity in plucked hair follicles predicts response to topical minoxidil treatment in Brazilian female pattern hair loss patients
Hair enzyme activity predicts minoxidil success in Brazilian women with hair loss.
research Minoxidil and its use in hair disorders: a review
Minoxidil effectively treats hair loss, but use cautiously and monitor side effects.
research Clinical utility and validity of minoxidil response testing in androgenetic alopecia
Minoxidil response testing helps treat hair loss effectively and safely.
research Novel enzymatic assay predicts minoxidil response in the treatment of androgenetic alopecia
New test predicts if hair loss treatment will work.
research Minoxidil Use in Dermatology, Side Effects and Recent Patents
Minoxidil treats hair loss, promotes growth, has side effects, and has recent patents.
Related
research Minoxidil Sulfotransferase Enzymatical Activity in Plants: A Novel Paradigm in Increasing Minoxidil Response in Androgenetic Alopecia
Some plants like spinach, broccoli, and matcha may boost the effectiveness of the hair growth drug minoxidil.
research Deterioration of scalp environment by exogenous factors and its influence on hair growth promoting effect of minoxidil
research Scalp Psoriasiform Contact Dermatitis with Acute Telogen Effluvium due to Topical Minoxidil Treatment
Minoxidil treatment for hair loss can cause scalp allergy and severe hair loss.
research [Effect of minoxidil on hair growth in androgenic alopecia in women].
Minoxidil helps stimulate hair growth and reduce hair loss in women with androgenic alopecia.
research Topical minoxidil in male pattern baldness: Effects of discontinuation of treatment
Stopping minoxidil treatment resumes balding; continuous use needed for results.
research Topical minoxidil (3%) in extensive alopecia areata, including long-term efficacy
3% topical minoxidil effectively treats extensive alopecia areata with few side effects.