Coming full circle (almost): Low dose oral minoxidil for alopecia
March 2021
in “Journal of The American Academy of Dermatology”
TLDR Low-dose oral minoxidil is an effective and safe treatment for hair loss.
Low-dose oral minoxidil (LDOM), at doses under 5 mg daily, has been explored as a treatment for various forms of alopecia. Randolph and Tosti reviewed 16 studies involving 622 patients and found LDOM to be an effective and well-tolerated alternative, particularly for those who have difficulty with topical formulations. No severe cardiopulmonary adverse reactions were reported, but caution is still advised with monitoring for blood pressure, heart rate, and fluid retention. Beach et al's retrospective study of 74 patients prescribed LDOM (1.25 mg daily for at least 3 months) showed increased scalp hair growth in 65% and decreased hair shedding in 27%, with facial hypertrichosis in 43% and hypotensive symptoms in 8%. LDOM was particularly effective in patients with nonscarring alopecia. The author, Warren R. Heymann, MD, acknowledges the potential of LDOM as a reasonable alternative for many alopecia patients.
View this study on jaad.org →
Cited in this study
research Oral minoxidil treatment for hair loss: A review of efficacy and safety
Oral minoxidil promotes hair growth but may cause side effects; needs monitoring.
research Low-dose oral minoxidil for treating alopecia: A 3-year North American retrospective case series
Low-dose oral minoxidil is an effective and well-tolerated treatment for hair growth in alopecia patients.
research Low‐dose oral minoxidil as treatment for non‐scarring alopecia: a systematic review
Low-dose oral minoxidil effectively treats non-scarring hair loss with some side effects like hypertrichosis and postural hypotension.
Related
research Minoxidil-induced hypertrichosis in a child with alopecia areata
A child used a hair growth lotion for hair loss, but it caused excessive hair growth on his face and neck instead.
research Topical Minoxidil
Minoxidil promotes hair regrowth, but more research needed for effectiveness and response factors.
research Alopecia areata treated with topical minoxidil
Topical minoxidil can help hair regrowth in alopecia areata patients, but maintaining the growth after stopping treatment is inconsistent.