Male Androgenetic Alopecia

January 2000

De Groot Lj, George P. Chrousos, Dungan K, Kenneth R. Feingold, Ashley B. Grossman, Jerome M. Hershman, Christoph Koch, Márta Korbonits, Robert I McLachlan, Mark New, Purnell J, Rebar R, Frederick R. Singer, Aaron I. Vinik

male androgenetic alopecia MAA androgens hair cycle development follicular miniaturization inflammation topical minoxidil oral finasteride hair transplantation Rogaine Propecia

TLDR Male androgenetic alopecia (MAA) is a common, hereditary hair loss condition in men, linked to heart disease, and can be treated with minoxidil, finasteride, or hair transplantation.

Male androgenetic alopecia (MAA) is the most common form of hair loss in men, affecting 30-50% of men by age 50. MAA occurs in a highly reproducible pattern, preferentially affecting the temples, vertex, and mid-frontal scalp. Hair loss impacts self-image and can cause anxiety and depression. MAA is a risk factor for arterial stiffness and cardiovascular disease. It is a hereditary condition, with genetics accounting for approximately 80% of predisposition. Normal levels of androgens can cause hair loss in genetically susceptible individuals. The key features of MAA are alteration in hair cycle development, follicular miniaturization, and inflammation. Treatment options include topical minoxidil and oral finasteride, which prevent further hair loss but only partially reverse baldness. Hair transplantation is also an option.

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